Regio- and diastereoselective nickel-catalyzed allylation of aromatic aldehydes with α-halo-β,β-difluoropropene derivatives.

نویسندگان

  • Xiaowei Lin
  • Feng Zheng
  • Feng-Ling Qing
چکیده

A one-pot nickel-catalyzed allylation of aromatic aldehydes with α-halo-β,β-difluoropropene-containing compounds promoted by ZnEt(2) under mild conditions was described. The reaction displays moderate to good regio- and diastereoselectivity, tolerates a wide range of functional groups, and provides an efficient method for the synthesis of γ-fluorinated homoallylic alcohols.

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عنوان ژورنال:
  • The Journal of organic chemistry

دوره 77 19  شماره 

صفحات  -

تاریخ انتشار 2012